David J Topham Selected Research

Integrin alpha1beta1

10/2014	Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus.
4/2010	Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
10/2007	The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection.
2/2004	The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection.

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David J Topham Research Topics

Disease

63	Infections 04/2022 - 10/2003
56	Human Influenza (Influenza) 02/2022 - 10/2003
16	Virus Diseases (Viral Diseases) 01/2020 - 03/2006
6	Respiratory Syncytial Virus Infections 01/2021 - 01/2018
5	COVID-19 01/2022 - 01/2020
4	Influenza in Birds (Avian Flu) 01/2018 - 07/2007
3	Inflammation (Inflammations) 01/2020 - 09/2013
2	Convalescence 01/2021 - 07/2015
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2017 - 08/2013
2	Reinfection 04/2010 - 07/2007
2	Neoplasms (Cancer) 11/2007 - 07/2006
1	Chickenpox 01/2021
1	Lymphoma (Lymphomas) 01/2021
1	Herpes Zoster 01/2021
1	Orthomyxoviridae Infections 06/2020
1	Premature Birth (Birth, Premature) 01/2020
1	Pneumonia (Pneumonitis) 01/2020
1	Superinfection 01/2020
1	Breast Neoplasms (Breast Cancer) 04/2019
1	Gastroenteritis 05/2017
1	Bacterial Infections (Bacterial Infection) 01/2017
1	Cerebral Malaria 07/2012
1	Smallpox (Variola) 02/2010
1	Vaccinia 02/2010
1	Pathologic Processes 04/2009

Drug/Important Bio-Agent (IBA)

25	VaccinesIBA 02/2022 - 02/2006
25	Proteins (Proteins, Gene)FDA Link 02/2022 - 02/2006
19	AntibodiesIBA 02/2022 - 07/2010
15	AntigensIBA 12/2020 - 09/2005
14	Immunoglobulin G (IgG)IBA 01/2022 - 10/2003
13	Hemagglutinins (Hemagglutinin)IBA 03/2021 - 07/2007
11	Influenza Vaccines (Influenza Vaccine)FDA Link 03/2021 - 01/2009
11	EpitopesIBA 01/2020 - 09/2005
9	CytokinesIBA 01/2020 - 07/2007
7	Peptides (Polypeptides)IBA 08/2020 - 02/2006
6	Amino Acids FDA Link 10/2018 - 09/2014
5	InterferonsIBA 01/2021 - 11/2016
5	IntegrinsIBA 01/2020 - 04/2007
5	Neutralizing AntibodiesIBA 01/2018 - 01/2009
4	Viral ProteinsIBA 12/2018 - 08/2013
4	Antiviral Agents (Antivirals)IBA 12/2018 - 08/2013
4	Integrin alpha1beta1IBA 10/2014 - 02/2004
3	Immunoglobulin A (IgA)IBA 01/2022 - 10/2003
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2017
3	RNA (Ribonucleic Acid)IBA 01/2021 - 09/2014
3	Neuraminidase (Sialidase)IBA 10/2018 - 09/2005
3	Biological ProductsIBA 11/2011 - 04/2009
2	Messenger RNA (mRNA)IBA 01/2022 - 09/2014
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2018
2	ChemokinesIBA 01/2020 - 09/2015
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 01/2018 - 07/2006
2	Monoclonal AntibodiesIBA 01/2018 - 06/2016
2	LigandsIBA 01/2016 - 03/2009
2	aluminum sulfate (alum)IBA 11/2013 - 02/2006
2	Interleukin-2 (IL2)IBA 01/2012 - 02/2006
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 02/2010 - 01/2009
2	CollagenIBA 04/2007 - 02/2004
1	Anti-Bacterial Agents (Antibiotics)IBA 04/2022
1	IgG Receptors (Fc gamma RI)IBA 01/2022
1	2019-nCoV Vaccine mRNA-1273IBA 01/2022
1	BNT162 VaccineIBA 01/2022
1	COVID-19 VaccinesIBA 01/2022
1	MicroRNAs (MicroRNA)IBA 11/2021
1	sperm releasing substanceIBA 01/2021
1	16S Ribosomal RNAIBA 01/2021
1	Immunoglobulin M (IgM)IBA 12/2020
1	SuperantigensIBA 01/2020
1	Androgen Receptors (Androgen Receptor)IBA 01/2020
1	AndrogensIBA 01/2020
1	Dihydrotestosterone (Androstanolone)IBA 01/2020
1	Testosterone (Sustanon)FDA Link 01/2020
1	Chemokine ReceptorsIBA 01/2020
1	SARS-CoV-2 spike proteinIBA 01/2020
1	FluBlokIBA 11/2019
1	Respiratory Syncytial Virus VaccinesIBA 01/2018
1	Blood Group Antigens (Blood Groups)IBA 05/2017
1	Blocking AntibodiesIBA 05/2017
1	Immune Sera (Antisera)IBA 01/2017
1	Linoleic Acid (Linoleate)IBA 01/2017
1	Double-Stranded RNA (RNA, Double Stranded)IBA 11/2016
1	Cleavage And Polyadenylation Specificity FactorIBA 11/2016
1	Chemokine CXCL12IBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 01/2016
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 08/2015
1	Broadly Neutralizing AntibodiesIBA 07/2015
1	Codon (Codons)IBA 09/2014
1	Immunoglobulin E (IgE)IBA 11/2013
1	Subunit VaccinesIBA 11/2013
1	ActomyosinIBA 09/2013
1	Fibronectins (Fibronectin)IBA 09/2013
1	Indicators and Reagents (Reagents)IBA 06/2012
1	Interleukin-4 (Interleukin 4)IBA 01/2012
1	HLA-DR1 Antigen (HLA DR1 Antigen)IBA 01/2012
1	Interleukin-22 (IL-22)IBA 08/2010
1	Mitogen-Activated Protein Kinase Kinase Kinase 11IBA 05/2010
1	JNK Mitogen-Activated Protein KinasesIBA 05/2010
1	Viral AntibodiesIBA 02/2010
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 02/2010

Therapy/Procedure

2	Therapeutics 01/2021 - 07/2009
1	Lab-On-A-Chip Devices 01/2020